![]() A Cox proportional hazards regression model was used to determine the primary outcome, while cardiovascular death was assessed using Fine-Gray competing risk regression models. Patients included in the analysis had acute stroke from July 1, 2005, to December 31, 2010, with a subsequent onset of epilepsy before December 31, 2014. 2 To understand more about the theoretical concerns about the detrimental effects of ASM on survival, senior author Johan Zelano, MD, PhD, consultant neurologist, Sahlgrenska University Hospital, and colleagues conducted a population-based cohort study with 2577 poststroke patients using all-cause death as the primary outcome. Stroke is the most commonly identified cause of new-onset epilepsy in adults. ![]() ![]() Furthermore, those treated with lamotrigine (Lamictal) had significantly lower hazard of cardiovascular and all-cause death compared to those treated with carbamazepine (Tegretol), the reference study drug. A recently conducted cohort study using data from linked Swedish registries showed that mortality varies based on antiseizure medication (ASM) use for patients who develop poststroke epilepsy.
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